--- /dev/null
+/* PR target/82580 */
+/* { dg-do compile } */
+/* { dg-options "-O2" } */
+
+#ifdef __SIZEOF_INT128__
+typedef unsigned __int128 U;
+typedef signed __int128 S;
+#else
+typedef unsigned long long U;
+typedef signed long long S;
+#endif
+void bar (void);
+int f0 (U x, U y) { return x == y; }
+int f1 (U x, U y) { return x != y; }
+int f2 (U x, U y) { return x > y; }
+int f3 (U x, U y) { return x >= y; }
+int f4 (U x, U y) { return x < y; }
+int f5 (U x, U y) { return x <= y; }
+int f6 (S x, S y) { return x == y; }
+int f7 (S x, S y) { return x != y; }
+int f8 (S x, S y) { return x > y; }
+int f9 (S x, S y) { return x >= y; }
+int f10 (S x, S y) { return x < y; }
+int f11 (S x, S y) { return x <= y; }
+
+/* { dg-final { scan-assembler-times {\mset} 12 } } */